Endocrine Abstracts

Introduction: The simultaneous occurrence of two drug-induced thyroid dysfunctions is rare. We present a case of central hypothyroidism due to bexarotene (BXC), followed by Interferon-α (IFNα)-induced Graves’ disease (GD) thyrotoxicosis after 2 years.Case Report: A 56-year-old man with no prior thyroid disease was diagnosed with cutaneous T-cell lymphoma and commenced treatment with BXC 600 mg/day and IFNα 90 mg/week concurrently. Aft...

Introduction: The existence of clear differences between the biological course and clinical behaviour of minimally invasive (MI) and widely invasive (WI) follicular thyroid carcinomas (FTC) is still debatable. The present study was conducted to outline the clinical differences between MI and WI-FTC and evaluate outcomes in both tumors.Methods: We conducted a retrospective cohort study involving 80 cases of FTC. The comparison between MI-FTC and WI-FTC in...

Introduction: Pheochromocytomas are adrenomedullary catecholamine-secreting tumors. These account for <0.1% of all causes of hypertension and may be related to potentially fatal hypertensive crises. Can appear as sporadic tumors or associated with familial syndromes.Malignancy occurs in 15–20% of the cases and is characterized by local invasion or distant metastasis rather than capsular invasion. Tumor recurrence has been reported with a frequen...

Introduction: Simultaneous pancreas-kidney transplantation remains the best treatment option in type 1 diabetic patients with chronic kidney failure, providing a euglycemic state associated with an improvement on diabetic chronic complications. However, there are only a few studies addressing the potential ischemic deterioration of peripheral arterial disease, due to blood diverting from the iliac artery to the kidney graft.Aim: Evaluate diabetic foot le...

Introduction: Primary hyperaldosteronism (PHA) and pheochromocytoma are endocrine causes of secondary arterial hypertension. The association of hyperaldosteronism and pheochromocytoma is rare and the involved mechanisms are poorly understood. Either there is coexistence of the two diseases (pheochromocytoma with PHA) or the pheochromocytoma stimulates the production of aldosterone.Case Report: Male, 54 years old, referred to our department for type 2 dia...

Introduction: About 5% of the adult population has adrenal incidentaloma(AI) and its incidence increases with age. AACE guidelines recommend image and hormonal evaluation during 5 years in non functioning AI. The european’s guidelines advise against repeat evaluation in non-secretory AI that present with <4 cm and had benign features. According to recent studies, the risk of developing clinically relevant hormone secretion is <0.3%, in patients with previous non-f...

Introduction: The quality of life (QoL) of patients with Diabetes has been the subject of several studies worldwide. In Portugal, studies have shown that patients under intensive insulin therapy had worse results in QoL questionnaires. The introduction of interstitial glucose monitoring (IGM) appears to reduce the impact of insulin therapy on QoL.Objective: To assess whether IGM changes the quality of life of patients with diabetes, compared to the asses...

Introduction: Diabetes is a disease with great psychosocial impact and reduced quality of life (QoL), and psychosocial factors seem to be excellent predictors of clinical outcomes.Objective: Assess the relationship between the patient’s perception of diabetes management and its impact on QoL.Methods: Interview of patients with type 1 (T1D) and type 2 diabetes (T2D), using the ‘Appraisal of Diabetes Scale’ (ADS), a qu...

Introduction: Obesity is a multifactorial and chronic disease. Bariatric surgery (BS) is the most effective treatment. A prevalence of 45% of esophagitis and 40%-70% of gastritis after BS has been reported. We analysed the presence of gastroesophageal lesions in patients who underwent BS (By-pass Roux-en-Y(BP) and gastric sleeve(GS)) in our centre.Methods: Patients submitted to BS between 2018-2020 were included. We retrospectively analysed clinical data...

Introduction: Inferior petrosal sinus sampling (IPSS) has been considered to be the gold standard for differential diagnosis of Cushing’s Disease (CD) and ectopic ACTH secretion (EAS).Aim: To describe the experience of our centre in performing IPSS, its safety and efficacy; assess remission rates from transphenoidal surgery and clinical course; approach to the difficulty in the etiological diagnosis of ACTH-dependent Cushing’s Syndrome.<p c...